Understanding testicular single cell transcriptional atlas: from developmental complications to male infertility

MB Tirumalasetty, I Bhattacharya… - Frontiers in …, 2024 - frontiersin.org
Spermatogenesis is a multi-step biological process where mitotically active diploid (2n)
spermatogonia differentiate into haploid (n) spermatozoa via regulated meiotic …

Contraceptive efficacy: Determining the threshold for effective suppression based on sperm concentration, motility, and morphology

C Wang, CLR Barratt, DL Blithe - Andrology, 2024 - Wiley Online Library
Introdction Human spermatogenesis is a complex process that transforms spermatogonial
stem cells through mitosis and meiosis to spermatozoa. Testosterone is the key regulator of …

The landscape of RNA binding proteins in mammalian spermatogenesis

Y Li, Y Wang, YQ Tan, Q Yue, Y Guo, R Yan, L Meng… - Science, 2024 - science.org
Despite continuous expansion of the RNA binding protein (RBP) world, there is a lack of
systematic understanding of RBPs in the mammalian testis, which harbors one of the most …

Ginkgo biloba extract alleviates deltamethrin-induced testicular injury by upregulating SKP2 and inhibiting Beclin1-independent autophagy

H Wang, F Yang, J Ye, X Dai, H Liao, C Xing, Z Jiang… - Phytomedicine, 2024 - Elsevier
Background Male infertility is a worldwide concern that is associated with a decline in sperm
quality. Environmental pollutants such as deltamethrin (DM) have harmful effects on male …

Sperm chromatin accessibility's involvement in the intergenerational effects of stress hormone receptor activation

V Fischer, M Kretschmer, PL Germain, J Kaur… - Translational …, 2023 - nature.com
Dexamethasone is a stress hormone receptor agonist used widely in clinics. We and others
previously showed that paternal administration of dexamethasone in mice affects the …

RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility

H Choi, L Zhou, Y Zhao, J Dean - Nucleic Acids Research, 2024 - academic.oup.com
During meiosis, RNA polymerase II transcribes pachytene piRNA precursors with unusually
long and unspliced transcripts from discrete autosomal loci in the mouse genome. Despite …

Integrated single cell transcriptome sequencing analysis reveals species‐specific genes and molecular pathways for pig spermiogenesis

YD Zhao, CX Yang, ZQ Du - Reproduction in Domestic Animals, 2023 - Wiley Online Library
Mammalian spermatogenesis is a highly complicated and intricately organized process
involving spermatogonia propagation (mitosis) and meiotic differentiation into mature sperm …

Single‐cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila

X Chen, Y Qi, Q Huang, C Sun, Y Zheng, L Ji, Y Shi… - Aging …, 2024 - Wiley Online Library
Aging is a complex biological process leading to impaired functions, with a variety of
hallmarks. In the testis of Drosophila, the terminal epithelium region is involved in spermatid …

[HTML][HTML] The Intricate Functional Networks of Pre-mRNA Alternative Splicing in Mammalian Spermatogenesis

N Jiang, Y Li, L Yin, S Yuan, F Wang - International Journal of Molecular …, 2024 - mdpi.com
Spermatogenesis is a highly coordinated process that requires the precise expression of
specific subsets of genes in different types of germ cells, controlled both temporally and …

Exploring the Impact of Environmental Factors on Male Reproductive Health through Epigenetics

Y Zhang, JY Song, ZG Sun - Reproductive Toxicology, 2025 - Elsevier
Male infertility has become an increasingly severe global health issue, with its incidence
significantly rising over the past few decades. This paper delves into the crucial role of …