Ten percent of deaths worldwide are due to trauma, and it is the third most common cause of
death in the United States. Despite a profound upregulation in procoagulant mechanisms …

Platelets closely interface with the immune system to fight pathogens, target wound sites,
and regulate tissue repair. Natural platelet levels within the body can be depleted for a …

Platelets play a pivotal role in hemostasis and wound healing and conditional shape change
is an important component of platelet functionality. In normal circumstances, platelets travel …

Platelet concentrates (PCs) represent a blood transfusion product with a major concern for
safety as their storage temperature (20–24° C) allows bacterial growth, and their maximum …

Fixed ratio versus goal-directed therapy in trauma : Current Opinion in Anesthesiology Fixed
ratio versus goal-directed therapy in trauma : Current Opinion in Anesthesiology Log in or …

Introduction Cold-stored low titer group O whole blood (LTOWB) is increasingly utilized in
the initial resuscitation of exsanguinating trauma patients. We report on our early experience …

Objectives: Reduced platelet (PLT) function during storage has been shown for buffy-coat-
derived platelet concentrates (BCP) and apheresis platelet units (AP), while for whole blood …

Background Reductions in platelet (PLT) count and function are associated with poor
outcomes in trauma patients. We proposed to determine if patients expected to receive …

Hemorrhage after trauma remains a significant cause of preventable death. Trauma-induced
coagulopathy (TIC) at the time of hospital admission is associated with an impaired …

Background and Objectives Platelet has been linked to thrombosis in several studies.
Inflammation is closely intertwined with thrombosis and occurs consecutively; it is therefore …