One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

▪ Abstract De novo protein design has recently emerged as an attractive approach for
studying the structure and function of proteins. This approach critically tests our …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

We recently described general principles for designing ideal protein structures stabilized by
completely consistent local and nonlocal interactions. The principles relate secondary …

A tight turn in protein structure is defined as a site where (i) a polypeptide chain reverses its
overall direction, ie, leads the chain to fold back on itself by nearly 180°, and (ii) the amino …

The final goal of functional genomics is to determine the biological role for all of the genes in
a cell. At present, the genome-scale prediction of protein function is based primarily on the …

Three-dimensional conformation is the primary determinant of molecular properties. The
thermal energy available at room temperature typically equilibrates the accessible …

Combined IR and UV laser spectroscopic techniques in molecular beams merged with
theoretical approaches have proven to be an ideal tool to elucidate intrinsic structural …

The functional properties of a protein primarily depend on its three-dimensional (3D)
structure. These properties have classically been assigned, visualized and analysed on the …

The receptor for advanced glycation end products (RAGE) is a multiligand cell surface
macromolecule that plays a central role in the etiology of diabetes complications …