Peptide-based vaccines: current progress and future challenges
RJ Malonis, JR Lai, O Vergnolle - Chemical reviews, 2019 - ACS Publications
Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …
disease. In addition, the development of vaccines against chronic diseases has attracted …
Peptides for vaccine development
IW Hamley - ACS Applied Bio Materials, 2022 - ACS Publications
This review discusses peptide epitopes used as antigens in the development of vaccines in
clinical trials as well as future vaccine candidates. It covers peptides used in potential …
clinical trials as well as future vaccine candidates. It covers peptides used in potential …
Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate
Hepatitis C virus (HCV) infection affects approximately 58 million people and causes~
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …
Neutralizing antibodies evolve to exploit vulnerable sites in the HCV envelope glycoprotein E2 and mediate spontaneous clearance of infection
N Frumento, A Sinnis-Bourozikas, HT Paul, G Stavrakis… - Immunity, 2024 - cell.com
Individuals who clear primary hepatitis C virus (HCV) infections clear subsequent
reinfections more than 80% of the time, but the mechanisms are poorly defined. Here, we …
reinfections more than 80% of the time, but the mechanisms are poorly defined. Here, we …
Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection
T cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective
immunity in chronic viral infections and cancer. Limited knowledge exists of the initial viral …
immunity in chronic viral infections and cancer. Limited knowledge exists of the initial viral …
Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C
A Nishio, S Hasan, H Park, N Park, JH Salas… - Nature …, 2022 - nature.com
The increasing incidence of hepatitis C virus (HCV) infections underscores the need for an
effective vaccine. Successful vaccines to other viruses generally depend on a long-lasting …
effective vaccine. Successful vaccines to other viruses generally depend on a long-lasting …
Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 are responsible for cell entry,
with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a …
with E2 being the major target of neutralizing antibodies (NAbs). Here, we present a …
Sites of vulnerability in HCV E1E2 identified by comprehensive functional screening
JM Pfaff-Kilgore, E Davidson, K Kadash-Edmondson… - Cell reports, 2022 - cell.com
The E1 and E2 envelope proteins of hepatitis C virus (HCV) form a heterodimer that drives
virus-host membrane fusion. Here, we analyze the role of each amino acid in E1E2 function …
virus-host membrane fusion. Here, we analyze the role of each amino acid in E1E2 function …
Immune system control of hepatitis C virus infection
JD Stuart, E Salinas, A Grakoui - Current opinion in virology, 2021 - Elsevier
Hepatitis C virus (HCV) remains a global public health problem even though more than 95%
of infections can be cured by treatment with direct-acting antiviral agents. Resolution of …
of infections can be cured by treatment with direct-acting antiviral agents. Resolution of …
Hepatitis C virus associated hepatocellular carcinoma
Liver cancer is a global problem and hepatocellular carcinoma (HCC) accounts for about
85% of this cancer. In the USA, etiologies and risk factors for HCC include chronic hepatitis …
85% of this cancer. In the USA, etiologies and risk factors for HCC include chronic hepatitis …