Compounds known to be successful in the treatment of alcohol use disorder include the
aversive agent, Disulfiram, the glutamatergic NMDA receptor antagonist, Acamprosate, and …

Unhealthy alcohol consumption is a global health problem. Adverse individual, public
health, and socioeconomic consequences are attributable to harmful alcohol use …

Ghrelin is a peptide that is produced by endocrine cells that are primarily localized in the
stomach. Ghrelin receptors (GHSR) are expressed in the brain and periphery. Preclinical …

There is a substantial need for new pharmacological treatments of addiction, and appetite-
regulatory peptides are implied as possible candidates. Appetite regulation is complex and …

Abstract introduction: The number of medications approved for AUD is small and they
generally have limited efficacy. We need new pharmacotherapies for the management of …

Growth hormone secretagogue receptor 1a (GHSR1a), a member of the G protein-coupled
receptor (GPCR) family, is a functional receptor of ghrelin. The expression levels and …

The biological signals of hunger, satiety, and memory are interconnected. The role of the
hormone ghrelin in regulating feeding and memory makes ghrelin receptors attractive …

Ghrelin is an octanoylated peptide acting by the activation of the growth hormone
secretagogue receptor, namely, GHS-R1a. The involvement of ghrelin in several …

Alcohol use disorder (AUD) remains a significant public health concern, affecting around 5%
of adults worldwide. Novel pathways of damage have been described during the last years …

Aims The appetite regulating hormone leptin, which is mainly secreted from adipose tissue,
is an important regulator of food intake and modulator of reward-driven behavior. Leptin …