Viral pathogens present many challenges to organisms, driving the evolution of a myriad of
antiviral strategies to combat infections. A wide variety of viruses infect invertebrates …

Abstract The Mitogen-Activated Protein Kinase (MAPK) pathway represents one of the most
conserved signaling cascades in multicellular organisms, since its cytoplasmic components …

Gene set enrichment analysis (GSEA) plays an important role in large-scale data analysis,
helping scientists discover the underlying biological patterns over-represented in a gene list …

The Hippo pathway controls metazoan organ growth by regulating cell proliferation and
apoptosis. Many components have been identified, but our knowledge of the composition …

Purpose: Cisplatin-based chemotherapy is widely used for esophageal cancer, sometimes
in combination with surgery/radiotherapy, but poor response to chemotherapy is not …

A major objective of systems biology is to organize molecular interactions as networks and
to characterize information flow within networks. We describe a computational framework to …

Combinatorial interactions among transcription factors (TFs) play essential roles in
generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid …

BACKGROUND Recent work has shown that two codling moth (Cydia pomonella)
glutathione S‐transferase genes (GSTs), CpGSTd1 and CpGSTd3, can metabolize λ …

Insulin regulates an essential conserved signaling pathway affecting growth, proliferation,
and metabolism. To expand our understanding of the insulin pathway, we combine …

Analysis of high-throughput data increasingly relies on pathway annotation and functional
information derived from Gene Ontology. This approach has limitations, in particular for the …