Cardiac energy metabolism in heart failure

GD Lopaschuk, QG Karwi, R Tian, AR Wende… - Circulation …, 2021 - Am Heart Assoc
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

RNA modification in cardiovascular disease: implications for therapeutic interventions

C Wang, X Hou, Q Guan, H Zhou, L Zhou… - … and Targeted Therapy, 2023 - nature.com
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

[HTML][HTML] Epigenetics and microRNAs in cardiovascular diseases

RMW Colpaert, M Calore - Genomics, 2021 - Elsevier
Cardiovascular diseases are among the leading causes of mortality worldwide. Besides
environmental and genetic changes, these disorders can be influenced by processes which …

The emerging role of epigenetics in therapeutic targeting of cardiomyopathies

C Pagiatakis, V Di Mauro - International Journal of Molecular Sciences, 2021 - mdpi.com
Cardiomyopathies (CMPs) are a heterogeneous group of myocardial diseases accountable
for the majority of cases of heart failure (HF) and/or sudden cardiac death (SCD) worldwide …

Perinatal lead exposure promotes sex-specific epigenetic programming of disease-relevant pathways in mouse heart

LK Svoboda, K Wang, JM Goodrich, TR Jones… - Toxics, 2023 - mdpi.com
Environmental contaminants such as the metal lead (Pb) are associated with cardiovascular
disease, but the underlying molecular mechanisms are poorly understood. In particular, little …

Roles of Wnt signaling pathway and ROR2 receptor in embryonic development: an update review article

R Guo, QS Xing - Epigenetics Insights, 2022 - journals.sagepub.com
The Wnt family is a large class of highly conserved cysteine-rich secretory glycoproteins that
play a vital role in various cellular and physiological courses through different signaling …

Ischemic stroke induces cardiac dysfunction and alters transcriptome profile in mice

J Chen, J Gong, H Chen, X Li, L Wang, X Qian, K Zhou… - BMC genomics, 2021 - Springer
Background Stroke can induce cardiac dysfunction in the absence of primary cardiac
disease; however, the mechanisms underlying the interaction between the neurological …

[PDF][PDF] Cardiovascular disease biomarkers derived from circulating cell-free DNA methylation

RRC Cuadrat, A Kratzer, HG Arnal… - NAR Genomics and …, 2023 - academic.oup.com
Acute coronary syndrome (ACS) remains a major cause of worldwide mortality. The
syndrome occurs when blood flow to the heart muscle is decreased or blocked, causing …

Transcriptome and methylome of the supraoptic nucleus provides insights into the age-dependent loss of neuronal plasticity

D Thompson, AE Odufuwa, CA Brissette… - Frontiers in Aging …, 2023 - frontiersin.org
The age-dependent loss of neuronal plasticity is a well-known phenomenon that is poorly
understood. The loss of this capacity for axonal regeneration is emphasized following …

Sex-specific alterations in cardiac DNA methylation in adult mice by perinatal lead exposure

LK Svoboda, K Wang, TR Jones, JA Colacino… - International journal of …, 2021 - mdpi.com
Environmental factors play an important role in the etiology of cardiovascular diseases.
Cardiovascular diseases exhibit marked sexual dimorphism; however, the sex-specific …