The liver is the largest, important organ and the site for essential biochemical reactions in
the human body. It has the function to detoxify toxic substances and synthesize useful …

Continuously increasing understanding of the molecular triggers responsible for the onset of
diseases, paralleled by an equally dynamic evolution of chemical synthesis and screening …

Systemic toxicity testing forms the cornerstone for the safety evaluation of substances.
Pressures to move from traditional animal models to novel technologies arise from various …

Despite recent advances in biomaterial science, there is yet no culture system that supports
long-term culture expansion of human adult hepatocytes, while preserving continued …

In the current scenario where more and more products containing nanomaterials are on the
technological or pharmaceutical market, it is crucial to have a thorough knowledge of their …

Drug-induced liver injury (DILI) remains a great challenge and a major concern during late-
stage drug development. Induced pluripotent stem cells (iPSC) represent an exciting …

Hepatic cancer is one of the most widespread maladies worldwide that requires urgent
therapies and thus reliable means for testing anti-cancer drugs. The switch from two …

Organoid technology holds great promise for regenerative medicine. Recent studies show
feasibility for bile duct tissue repair in humans by successfully transplanting cholangiocyte …

Maintaining stable differentiated somatic cell function in culture is essential to a range of
biological endeavors. However, current technologies, employing, for example, primary …

Abstract The National Academy of Sciences publication, Toxicity Testing in the 21st Century:
A Vision and a Strategy, proposes a paradigm shift in toxicology from current animal-based …