Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …

The axon initial segment (AIS), located within the first 30 μm of the axon, has two essential
roles in generating action potentials and maintaining axonal identity. AIS assembly depends …

Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in
axons. How this membrane skeleton is developed and why it preferentially forms in axons …

SPTBN1 encodes βII-spectrin, the ubiquitously expressed β-spectrin that forms micrometer-
scale networks associated with plasma membranes. Mice deficient in neuronal βII-spectrin …

Actin, spectrin, and associated molecules form a periodic, submembrane cytoskeleton in the
axons of neurons. For a better understanding of this membrane-associated periodic skeleton …

Neurons are highly specialized cells of the nervous system that receive, process and
transmit electrical signals critical for normal brain function. Here, we review the intricate …

Spectrins are cytoskeletal proteins that are expressed ubiquitously in the mammalian
nervous system. Pathogenic variants in SPTAN1, SPTBN1, SPTBN2 and SPTBN4, four of …

The combination of genetics and genomics in Parkinson´ s disease has recently begun to
unveil molecular mechanisms possibly underlying disease onset and progression. In …

Giant ankyrin-B (ankB) is a neurospecific alternatively spliced variant of ANK2, a high-
confidence autism spectrum disorder (ASD) gene. We report that a mouse model for human …