There is currently a worldwide consensus and recognition of the undoubted health benefits
of the so-called Mediterranean diet, with its intake being associated with a lower risk of …

Oleanolic acid (OA) and its derivatives are widely found in diverse plants and are naturally
effective pentacyclic triterpenoid compounds with broad prophylactic and therapeutic roles …

Triterpenic acids are phytocompounds with a widespread range of biological activities that
have been the subject of numerous in vitro and in vivo studies. However, their underlying …

Hydroxytyrosol (HT), the main representative of polyphenols of olive oil, has been described
as one of the most powerful natural antioxidants, also showing anti-inflammatory …

Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient and
selective anticancer agents whose underlying mechanisms of action have been widely …

Maslinic acid (MA) is a natural triterpene from Olea europaea L. with multiple biological
properties. The aim of the present study was to examine MA's effect on cell viability (by the …

Melanoma is one of the most dangerous forms of skin cancer, characterized by early
metastasis and rapid development. In search for effective treatment options, much attention …

Natural products have always played an important role in pharmacotherapy, helping to
control pathophysiological processes associated with human disease. Thus, natural …

Cancer remains a major health problem worldwide due to its high mortality rate. New
therapeutic options highlight the importance of discovering new compounds that target the …

A set of 18 amide derivatives of oleanolic or maslinic acid has been semi-synthesised.
Twelve were diamine conjugates at C-28 of these triterpenic acids and the other six were …