Neurobiology of alcohol seeking behavior

E Domi, A Domi, L Adermark, M Heilig… - Journal of …, 2021 - Wiley Online Library
Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

Enkephalins and ACTH in the mammalian nervous system

E Duque-Díaz, O Alvarez-Ojeda, R Coveñas - Vitamins and Hormones, 2019 - Elsevier
The pentapeptides methionine-enkephalin and leucine-enkephalin belong to the opioid
family of peptides, and the non-opiate peptide adrenocorticotropin hormone (ACTH) to the …

Targeting the glucocorticoid receptors during alcohol withdrawal to reduce protracted neurocognitive disorders

D Béracochéa, N Mons, V David - Frontiers in psychiatry, 2019 - frontiersin.org
Persistent regional glucocorticoid (GC) dysregulation in alcohol-withdrawn subjects
emerges as a key factor responsible for protracted molecular and neural alterations …

Chronic alcohol-induced long-lasting working memory deficits are associated with altered histone H3K9 dimethylation in the prefrontal cortex

M De Clerck, M Manguin, N Henkous… - Frontiers in Behavioral …, 2024 - frontiersin.org
Introduction Epigenetic modifications have emerged as key contributors to the enduring
behavioral, molecular and epigenetic neuroadaptations during withdrawal from chronic …

High-dose baclofen attenuates insula activation during anticipatory anxiety in treatment-seeking alcohol dependant individuals: Preliminary findings from a pharmaco …

KC Morley, WB Logge, I Fraser, RW Morris… - European …, 2021 - Elsevier
The GABA B agonist, baclofen, has been shown to reduce alcohol consumption in patients
with alcohol use disorder and also those with comorbid anxiety. This study aimed to …

Baclofen for alcohol use disorder

R Agabio, R Saulle, S Rösner… - Cochrane Database of …, 2023 - cochranelibrary.com
Background Alcohol use disorder (AUD) is one of the most widespread psychiatric disorders
leading to detrimental consequences to people with this disorder and others. Worldwide, the …

Alcohol CHAPTER9 Dependence Conceptualized as a Stress Disorder

LF Vendruscolo, GF Koob - The Oxford Handbook of Stress and …, 2019 - books.google.com
Alcohol use disorder is a chronically relapsing disorder that involves (1) compulsivity to seek
and take alcohol,(2) difficulty in limiting alcohol intake, and (3) emergence of a negative …

Baclofen but not diazepam alleviates alcohol-seeking behavior and hypothalamic–pituitary–adrenal axis dysfunction in stressed withdrawn mice

Y Rabat, N Henkous, M Corio, X Nogues… - Frontiers in …, 2019 - frontiersin.org
This study compares the impact of repeated injections of baclofen (an agonist of GABAB
receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) …

Preventive effects of baclofen but not diazepam on hippocampal memory and glucocorticoid alterations after prolonged alcohol withdrawal in mice

H Nadia, M Fabienne, C Pierard, M Nicole… - Frontiers in …, 2022 - frontiersin.org
Our study aims at comparing in C57/Bl male mice, the impact of repeated injections of
baclofen (an agonist of GABAB receptor) or diazepam (a benzodiazepine acting through a …

Hypothalamic-pituitary-adrenocortical response in alcohol-dependent patients during baclofen treatment and association with clinical outcome: Preliminary results

W Logge, T Hurzeler, S Arunogiri, E Towers, A Baillie… - Alcohol, 2023 - Elsevier
Baclofen has been shown to reduce alcohol consumption in some individuals with alcohol
use disorder. This preliminary study aimed to evaluate i) the effect of baclofen versus …