Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Enzymatic carbon–sulfur bond formation in natural product biosynthesis

KL Dunbar, DH Scharf, A Litomska… - Chemical …, 2017 - ACS Publications
Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Secondary metabolite production and the safety of industrially important members of the Bacillus subtilis group

CR Harwood, JM Mouillon, S Pohl… - FEMS microbiology …, 2018 - academic.oup.com
Members of the 'Bacillus subtilis group'include some of the most commercially important
bacteria, used for the production of a wide range of industrial enzymes and fine …

The expanding structural variety among bacteriocins from Gram-positive bacteria

JZ Acedo, S Chiorean, JC Vederas… - FEMS microbiology …, 2018 - academic.oup.com
Bacteria use various strategies to compete in an ecological niche, including the production
of bacteriocins. Bacteriocins are ribosomally synthesized antibacterial peptides, and it has …

Transporters of glucose and other carbohydrates in bacteria

JM Jeckelmann, B Erni - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
Glucose arguably is the most important energy carrier, carbon source for metabolites and
building block for biopolymers in all kingdoms of life. The proper function of animal organs …

[HTML][HTML] Comparison of antibiotic resistance mechanisms in antibiotic-producing and pathogenic bacteria

H Ogawara - Molecules, 2019 - mdpi.com
Antibiotic resistance poses a tremendous threat to human health. To overcome this problem,
it is essential to know the mechanism of antibiotic resistance in antibiotic-producing and …

[HTML][HTML] Phages carry interbacterial weapons encoded by biosynthetic gene clusters

A Dragoš, AJC Andersen, CN Lozano-Andrade… - Current Biology, 2021 - cell.com
Bacteria produce diverse specialized metabolites that mediate ecological interactions and
serve as a rich source of industrially relevant natural products. Biosynthetic pathways for …

Natural bacterial isolates as an inexhaustible source of new bacteriocins

J Lozo, L Topisirovic, M Kojic - Applied Microbiology and Biotechnology, 2021 - Springer
Microorganisms isolated from various traditionally fermented food products prepared in
households without commercial starter cultures are designated as natural isolates. In …

[HTML][HTML] The mannose phosphotransferase system (Man-PTS)-Mannose transporter and receptor for bacteriocins and bacteriophages

JM Jeckelmann, B Erni - Biochimica et Biophysica Acta (BBA) …, 2020 - Elsevier
Mannose transporters constitute a superfamily (Man-PTS) of the Phosphoenolpyruvate
Carbohydrate Phosphotransferase System (PTS). The membrane complexes are …

Targeted Peptide Modification Using an Engineered Bacterial N-Glycosyltransferase

AB Smith, JR Chekan - ACS Catalysis, 2024 - ACS Publications
Many biosynthetic enzymes involved in the production of ribosomally synthesized and post-
translationally modified peptides (RiPPs) in prokaryotic organisms often possess two distinct …