Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

The human choroid is a heterogeneous, highly vascular connective tissue that dysfunctions
in age-related macular degeneration (AMD). In this study, we performed single-cell RNA …

Brain-resident macrophages, microglia, have been proposed to have an active role in
synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Here …

Single-cell RNA-sequencing (scRNA-seq) enables researchers to quantify transcriptomes of
thousands of cells simultaneously and study transcriptomic changes between cells. scRNA …

Apical cilia on epithelial cells defend the lung by propelling pathogens and particulates out
of the respiratory airways. Ciliated cells produce ATP that powers cilia beating by densely …

Differential expression (DE) analysis is a necessary step in the analysis of single-cell RNA
sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) data. Unlike …

Background A common feature of single-cell RNA-seq (scRNA-seq) data is that the number
of cells in a cell cluster may vary widely, ranging from a few dozen to several thousand. It is …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious and poorly
understood disease. To understand immune dysregulation in ME/CFS, we use single-cell …

SUMMARY ME/CFS is a serious and poorly understood disease. To understand immune
dysregulation in ME/CFS, we used single-cell RNA-seq (scRNA-seq) to examine immune …

Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the
transcriptome, composition, and function of large and small airway epithelia in people with …