The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

The γ‐aminobutyric acid type A (GABAA) receptor represents an elementary switching
mechanism integral to the functioning of the central nervous system and a locus for the …

Cenobamate is a novel antiepileptic drug under investigation for use in patients with focal
(partial-onset) seizures. To understand its potential molecular mechanism of action, the …

The γ-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is composed of
distinct proteins embedded in the neuronal plasma membrane, is important for several …

The neurosteroid pregnenolone sulphate (PS) potentiates N‐methyl‐d‐aspartate (NMDA)
receptor mediated responses in various neuronal preparations. The NR1 subunit can …

The most abundant inhibitory neurotransmitter in the central nervous system, γ-aminobutyric
acid (GABA), exerts its main effects via a GABAA receptor that gates a chloride channel in …

In neurological and behavioral studies in mice, rats, dogs and squirrel monkeys, the
imidazobenzodiazepinone Ro 15-1788 acted as a potent benzodiazepine antagonist. The …

▪ Abstract Transmitter receptor diversity often indicates differences in transmitter receptor
transduction mechanisms. This is not the case for γ-aminobutyric acid subtype A (GABAA) …

Recent findings suggest that steroids with sedative-hypnotic properties interact specifically
with the γ-aminobutyric acid A/benzodiazepine receptor-chloride ionophore complex …

Abstract Diazepam and (--)-pentobarbital each potentiate the increase in chloride ion
conductance produced by gamma-aminobutyric acid (GABA) i voltage-clamped mouse …