[HTML][HTML] Targeted delivery of anti-osteoporosis therapy: Bisphosphonate-modified nanosystems and composites

S Shi, H Duan, X Ou - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Osteoporosis (OP) constitutes a significant health concern that profoundly affects individuals'
quality of life. Bisphosphonates, conventional pharmaceuticals widely employed in OP …

To investigate the mechanism of Yiwei Decoction in the treatment of premature ovarian insufficiency-related osteoporosis using transcriptomics, network …

W Fan, Y Meng, J Zhang, M Li, Y Zhang, X Qu, X Xiu - Scientific Reports, 2023 - nature.com
To investigate the molecular mechanism of Yiwei Decoction (YWD) in preventing Premature
ovarian insufficiency (POI)-related osteoporosis from the hypothalamic perspective, and to …

Network pharmacology analysis and experimental validation to explore the mechanism of kaempferol in the treatment of osteoporosis

Q Dong, G Ren, Y Li, D Hao - Scientific Reports, 2024 - nature.com
Osteoporosis (OP) is a prevalent global disease characterized by bone mass loss and
microstructural destruction, resulting in increased bone fragility and fracture susceptibility …

gCTRP3 inhibits oophorectomy‑induced osteoporosis by activating the AMPK/SIRT1/Nrf2 signaling pathway in mice

X Zhang, D Zhang, H Zhao, J Qin… - Molecular …, 2024 - spandidos-publications.com
C1q/tumor necrosis factor‑related protein 3 (CTRP3) expression is markedly reduced in the
serum of patients with osteoporosis. The present study aimed to investigate whether CTRP3 …

Bu-Sui-Dan Enhances Osteoblast Differentiation by Upregulating VGLL4 to Counteract TEAD4-Mediated RUNX2 Transcription Suppression in Ovariectomized Rats

C Li, X Liu, X Chen, J Zhang, Y Liao, Z Fan… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Postmenopausal osteoporosis (PMOP) has been
considered as a major causative factor for bone-joint pain and inducing pathologic fractures …

Assessment of Bone Regeneration Potential for a 6-Bromoindirubin-3'-Oxime (Bio) Encapsulated Chitosan Based Scaffold in a Mouse Critical Sized Bone Defect …

CJ Agnes, L Li, D Bertrand, M Murshed… - Available at SSRN … - papers.ssrn.com
Abstract Development of an effective treatment to guide bone repair in critical size bone
defect applications remains a major unmet challenge. Current clinical gold standards …