Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It
targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts …

NLRP3, a member of nucleotide-binding domain-(NOD) like receptor family, can be found in
large varieties of immune and non-immune cells. Upon activation, the NLRP3, apoptosis …

Summary The interleukin (IL)‐1 family of cytokines is a central regulator of a myriad of
immunological responses. It comprises several cytokines, including those belonging to the …

The IL-1 family consists of 11 cytokines, 7 ligands with agonist activity (IL-1α, IL-1β, IL-18, IL-
33, IL-36α, IL-36β, IL-36γ) and four members with antagonistic activities [IL-1 receptor …

Systemic sclerosis is an autoimmune disorder characterized by inflammation and a
progressive fibrosis affecting the skin and visceral organs. Over the last two decades, it …

Systemic sclerosis (SSc) is a connective tissue disease secondary to three cardinal
pathological features: immune-system alterations, diffuse microangiopathy, and fibrosis …

Introduction NOD-like receptor family pyrin domain containing 3 (NLRP3) can sense a
plethora of exogenous and endogenous dangers. Upon activation, a multimeric protein …