The lymphocytes, T, B, and NK cells, and a proportion of dendritic cells (DCs) have a
common developmental origin. Lymphocytes develop from hematopoietic stem cells via …

Nuclear factor-κB (NF-κB) is an inducible transcription factor controlled by two principal
signaling cascades, each activated by a set of signal ligands: the classical/canonical NF-κB …

Epstein–Barr virus (EBV) establishes a lifelong latent infection in host B cells and is
associated with the development of a variety of malignancies. The viral LMP2A protein …

Engagement of the B‐cell antigen receptor (BCR) or its precursor, the pre‐BCR, induces a
cascade of biochemical reactions that regulate the differentiation, selection, survival, and …

BAFF is an important prosurvival cytokine for mature B cells. However, previous studies
have shown that BAFFR is already expressed at the immature B cell stage, and that the …

Limited responsiveness to inflammatory cytokines is a feature of adult hematopoietic stem
cells and contributes to the relative quiescence and durability of the stem cell population in …

The possibility of links between phsychosocial factors and cancer incidence and
progression has generated considerable scientific and public interest. Tachykinins …

Early B-cell development is an ordered and highly regulated process with alternating
phases of cell proliferation and differentiation leading to B cells with the ability to recognize …

Bcr-abl kinase inhibitors have provided proof of principal that targeted therapy holds great
promise for the treatment of cancer. However, despite the success of these agents in treating …

The thymus provides a unique environment for the development of T lymphocytes from bone
marrow‐derived progenitor cells. Several environmental factors have been identified that …