What are the respiratory effects of e-cigarettes?

JE Gotts, SE Jordt, R McConnell, R Tarran - bmj, 2019 - bmj.com
Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that
generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable …

European position statement on lung cancer screening

M Oudkerk, A Devaraj, R Vliegenthart… - The Lancet …, 2017 - thelancet.com
Lung cancer screening with low-dose CT can save lives. This European Union (EU) position
statement presents the available evidence and the major issues that need to be addressed …

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking

Z Huang, S Sun, M Lee, AY Maslov, M Shi… - Nature …, 2022 - nature.com
Although lung cancer risk among smokers is dependent on smoking dose, it remains
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …

[HTML][HTML] Non-small cell lung cancer: current treatment and future advances

C Zappa, SA Mousa - Translational lung cancer research, 2016 - ncbi.nlm.nih.gov
Lung cancer has a poor prognosis; over half of people diagnosed with lung cancer die
within one year of diagnosis and the 5-year survival is less than 18%. Non-small cell lung …

Lung cancer screening, version 3.2018, NCCN clinical practice guidelines in oncology

DE Wood, EA Kazerooni, SL Baum, GA Eapen… - Journal of the National …, 2018 - jnccn.org
Lung cancer is the leading cause of cancer-related mortality in the United States and
worldwide. Early detection of lung cancer is an important opportunity for decreasing …

Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

S Novello, F Barlesi, R Califano, T Cufer… - Annals of …, 2016 - annalsofoncology.org
Primary lung cancer remains the most common malignancy after non-melanocytic skin
cancer, and deaths from lung cancer exceed those from any other malignancy worldwide [1] …

Deconstructing the sources of genotype-phenotype associations in humans

AI Young, S Benonisdottir, M Przeworski, A Kong - Science, 2019 - science.org
Efforts to link variation in the human genome to phenotypes have progressed at a
tremendous pace in recent decades. Most human traits have been shown to be affected by a …

[HTML][HTML] Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

J Shi, K Shiraishi, J Choi, K Matsuo, TY Chen… - Nature …, 2023 - nature.com
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …

Pleiotropy in complex traits: challenges and strategies

N Solovieff, C Cotsapas, PH Lee, SM Purcell… - Nature Reviews …, 2013 - nature.com
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

Epidemiology of lung cancer: Diagnosis and management of lung cancer: American College of Chest Physicians evidence-based clinical practice guidelines

AJ Alberg, MV Brock, JG Ford, JM Samet, SD Spivack - Chest, 2013 - Elsevier
Background Ever since a lung cancer epidemic emerged in the mid-1900s, the
epidemiology of lung cancer has been intensively investigated to characterize its causes …