The neuro-endocrinological role of microbial glutamate and GABA signaling
R Mazzoli, E Pessione - Frontiers in microbiology, 2016 - frontiersin.org
Gut microbiota provides the host with multiple functions (eg, by contributing to food
digestion, vitamin supplementation, and defense against pathogenic strains) and interacts …
digestion, vitamin supplementation, and defense against pathogenic strains) and interacts …
Dysregulation of Nrf2 in hepatocellular carcinoma: role in cancer progression and chemoresistance
The liver executes versatile functions and is the chief organ for metabolism of
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …
[HTML][HTML] Opposing effects of fasting metabolism on tissue tolerance in bacterial and viral inflammation
Acute infections are associated with a set of stereotypic behavioral responses, including
anorexia, lethargy, and social withdrawal. Although these so-called sickness behaviors are …
anorexia, lethargy, and social withdrawal. Although these so-called sickness behaviors are …
Valproic acid pathway: pharmacokinetics and pharmacodynamics
Valproic acid (VPA) is a branched short-chain fatty acid derived from naturally occurring
valeric acid. VPA is used primarily in the treatment of epilepsy and seizures, but is also used …
valeric acid. VPA is used primarily in the treatment of epilepsy and seizures, but is also used …
Adverse drug reactions induced by valproic acid
RM Nanau, MG Neuman - Clinical biochemistry, 2013 - Elsevier
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …
An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy
MJ Millan - Neuropharmacology, 2013 - Elsevier
Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …
development of the brain, leading to deficits in language, cognition, motor behaviour and …
Therapeutic potential for HDAC inhibitors in the heart
TA McKinsey - Annual review of pharmacology and toxicology, 2012 - annualreviews.org
Reversible protein acetylation provides a central mechanism for controlling gene expression
and cellular signaling events. Two pharmacological inhibitors of protein deacetylation are …
and cellular signaling events. Two pharmacological inhibitors of protein deacetylation are …
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts
NH Pipalia, CC Cosner, A Huang… - Proceedings of the …, 2011 - National Acad Sciences
Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1
protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified …
protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified …
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism
MA Cavasin, K Demos-Davies, TR Horn… - Circulation …, 2012 - Am Heart Assoc
Rationale: Histone deacetylase (HDAC) inhibitors are efficacious in models of hypertension-
induced left ventricular heart failure. The consequences of HDAC inhibition in the context of …
induced left ventricular heart failure. The consequences of HDAC inhibition in the context of …
The impact of anti-epileptic drugs on growth and bone metabolism
Epilepsy is a common neurological disorder worldwide and anti-epileptic drugs (AEDs) are
always the first choice for treatment. However, more than 50% of patients with epilepsy who …
always the first choice for treatment. However, more than 50% of patients with epilepsy who …