Mesenchymal stem cell therapy for ischemic stroke: a look into treatment mechanism and therapeutic potential

J Li, Q Zhang, W Wang, F Lin, S Wang, J Zhao - Journal of neurology, 2021 - Springer
Stroke, a global disease with a high disability rate, has limited options for functional
rehabilitation and results in an adverse impact on patients' lives. In recent years …

Mechanical roles of F-actin in the differentiation of stem cells: a review

YL Fan, HC Zhao, B Li, ZL Zhao… - ACS biomaterials science …, 2019 - ACS Publications
In the development and differentiation of stem cells, mechanical forces associated with
filamentous actin (F-actin) play a crucial role. The present review aims to reveal the …

[HTML][HTML] Base-editing-mediated R17H substitution in histone H3 reveals methylation-dependent regulation of Yap signaling and early mouse embryo development

G Yang, C Zhou, R Wang, S Huang, Y Wei, X Yang… - Cell reports, 2019 - cell.com
The coactivator-associated arginine methyltransferase CARM1 catalyzes the methylation of
histone H3 arginine 17/26 (H3R17/26me) and non-histone proteins at arginine residues to …

Culture conditions of mouse ESCs impact the tumor appearance in vivo

C Tian, J Wang, X Ye, J Chen, R Zheng, H Yu, J Li… - Cell Reports, 2023 - cell.com
Various culture conditions by small molecules have been explored to extend pluripotency of
stem cells, but their impacts on cell fate in vivo remain elusive. We systematically compared …

Hormones induce the formation of luminal-derived basal cells in the mammary gland

W Song, R Wang, W Jiang, Q Yin, G Peng, R Yang… - Cell Research, 2019 - nature.com
In the mammary gland, it is widely believed that the luminal cells are unipotent after birth,
contributing only to the luminal compartment in normal development. Here, by lineage …

Base editing‐mediated perturbation of endogenous PKM1/2 splicing facilitates isoform‐specific functional analysis in vitro and in vivo

J Lin, S Wu, Q Shen, J Liu, S Huang, G Peng… - Cell …, 2021 - Wiley Online Library
Objectives PKM1 and PKM2, which are generated from the alternative splicing of PKM gene,
play important roles in tumourigenesis and embryonic development as rate‐limiting …

Remyelination in PNS and CNS: Current and upcoming cellular and molecular strategies to treat disabling neuropathies

S Momenzadeh, MS Jami - Molecular Biology Reports, 2021 - Springer
Myelin is a lipid-rich nerve cover that consists of glial cell's plasmalemma layers and
accelerates signal conduction. Axon-myelin contact is a source for many developmental and …

Signaling pathways influencing stem cell self-renewal and differentiation

M Tiwari, S Bhattacharyya, D Subramanyam - Stem Cells and Aging, 2021 - Elsevier
Embryonic stem cells (ESCs) isolated from the inner cell mass of the blastocyst have the
ability to self-renew and to differentiate into all three germ layers. Due to these properties …