T and B cells express most cholinergic system components—eg, acetylcholine (ACh),
choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic …

Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

Marine snails of the genus Conus are a large family of predatory gastropods with an
unparalleled molecular diversity of pharmacologically active compounds in their venom …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate
synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release …

Acetylcholine is produced in the spleen in response to vagus nerve activation; however, the
effects on antibody production have been largely unexplored. Here, we use a chronic vagus …

Acetylcholine (ACh) is the classical neurotransmitter in the cholinergic nervous system.
However, ACh is now known to regulate various immune cell functions. In fact, T cells, B …

αO-Conotoxin GeXIVA is a selective α9α10 nicotinic acetylcholine receptor (nAChR)
inhibitor displaying two disulfide bonds that can form three isomers. The bead (GeXIVA [1 …

Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

Neuropathic pain is a complex and debilitating syndrome for which there are few effective
pharmacological treatments. Opioid‐based medications are initially effective for acute pain …

Nicotinic acetylcholine receptors (nAChRs) are widely expressed in or on various cell types
and have diverse functions. In immune cells nAChRs regulate proliferation, differentiation …