Alzheimer disease (AD) is a chronic neurodegenerative disease that accounts for 60–70%
of dementia and is the sixth leading cause of death in the United States. The pathogenesis …

Insulin‐degrading enzyme (IDE) function goes far beyond its known proteolytic role as a
regulator of insulin levels. IDE has a wide substrate promiscuity, degrading several proteins …

Despite decades of speculation that inhibiting endogenous insulin degradation might treat
type-2 diabetes,, and the identification of IDE (insulin-degrading enzyme) as a diabetes …

Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed
metalloprotease that degrades insulin and several other intermediate-size peptides. For …

Macrophage inflammatory protein‐1 (MIP‐1), MIP‐1α (CCL3) and MIP‐1β (CCL4) are
chemokines crucial for immune responses towards infection and inflammation. Both MIP‐1α …

Insulin-degrading enzyme (IDE) selectively degrades peptides, such as insulin, amylin, and
amyloid β (Aβ) that form toxic aggregates, to maintain proteostasis. IDE defects are linked to …

Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family,
which has been initially discovered as the enzyme responsible for insulin catabolism; …

Synthetic insulin analogues with a long lifetime are current drug targets for the therapy of
diabetic patients. The replacement of the interchain disulfide with a diselenide bridge, which …

Insulin-degrading enzyme (IDE) is a protease that cleaves insulin and other bioactive
peptides such as amyloid-β. Knockout and genetic studies have linked IDE to Alzheimer's …

Background Insulin is a vital peptide hormone that is a central regulator of glucose
homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it …