While great progress has been made in the understanding of neurological illnesses, the
pathologies, and etiologies that give rise to these diseases still remain an enigma, thus, also …

Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …

A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces
rapid and sustained antidepressant actions in depressed patients, addressing a major …

Effective pharmacotherapy for major depressive disorder remains a major challenge, as
more than 30% of patients are resistant to the first line of treatment (selective serotonin …

Background Ketamine elicits rapid onset antidepressant effects in patients with clinical
depression through mechanisms hypothesized to involve the genesis of neocortical …

Ample evidence has suggested the stress etiology of depression, but the underlying
mechanism is not fully understood yet. Here, we report that chronic social defeat stress …

Psychological stress affects a wide spectrum of brain functions and poses risks for many
mental disorders. However, effective therapeutics to alleviate or revert its deleterious effects …

Cognitive resilience is often defined as the ability to remain cognitively normal in the face of
insults to the brain. These insults can include disease pathology, such as plaques and …

A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is
the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of …