Salt Handling and Blood Pressure Salt intake is associated with blood pressure, but the
relationship is complex. This review highlights the interplay among renal salt transport, salt …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Background The repertoire of protein expression along the renal tubule depends both on
regulation of transcription and regulation of alternative splicing that can generate multiple …

Consumption of low dietary potassium, common with ultraprocessed foods, activates the
thiazide-sensitive sodium chloride cotransporter (NCC) via the w ith no (K) lysine …

Dietary potassium deficiency, common in modern diets, raises blood pressure and
enhances salt sensitivity. Potassium homeostasis requires a molecular switch in the distal …

Hypertension and chronic kidney disease (CKD) are complex traits representing major
global health problems 1, 2. Multiple genome-wide association studies have identified …

Dietary potassium deficiency activates thiazide-sensitive sodium chloride cotransport along
the distal nephron. This may explain, in part, the hypertension and cardiovascular mortality …

A dietary potassium load induces a rapid kaliuresis and natriuresis, which may occur even
before plasma potassium and aldosterone (aldo) levels increase. Here we sought to gain …

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets
(the SPAK/OSR1 kinases and the cation-Cl− cotransporters [CCCs]), comprise a signaling …

Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia
in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have …