The physical landscape of CAR-T synapse

Y Xiong, KA Libby, X Su - Biophysical Journal, 2024 - cell.com
Chimeric antigen receptor (CAR)-T cells form dynamic immunological synapses with their
cancer cell targets. After a CAR-antigen engagement, the CAR-T synapse forms, matures …

Mechanical regulation of lymphocyte activation and function

A Pathni, K Wagh, I Rey-Suarez… - Journal of Cell …, 2024 - journals.biologists.com
Mechanosensing, or how cells sense and respond to the physical environment, is crucial for
many aspects of biological function, ranging from cell movement during development to …

Mechanical force regulates the inhibitory function of PD-1

H Chen, Y Zhang, L Cui, J Fan, S Wu, H Zhou, Y Zhang… - bioRxiv, 2024 - biorxiv.org
The immune checkpoint molecule, programmed cell death 1 (PD-1), plays a pivotal role in
regulating T-cell function. Upon binding to its ligands, PD-L1 or PD-L2, PD-1 suppresses T …