Click chemistry: 1, 2, 3‐triazoles as pharmacophores

SG Agalave, SR Maujan… - Chemistry–An Asian …, 2011 - Wiley Online Library
Abstract The copper (I)‐catalyzed 1, 2, 3‐triazole‐forming reaction between azides and
terminal alkynes has become the gold standard of 'click chemistry'due to its reliability …

Cu-catalyzed azide− alkyne cycloaddition

M Meldal, CW Tornøe - Chemical reviews, 2008 - ACS Publications
The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

'Click'chemistry in polymer and materials science

WH Binder, R Sachsenhofer - Macromolecular Rapid …, 2007 - Wiley Online Library
The modification of polymers after the successful achievement of a polymerization process
represents an important task in macromolecular science. Cycloaddition reactions, among …

Click chemistry reactions in medicinal chemistry: Applications of the 1, 3‐dipolar cycloaddition between azides and alkynes

GC Tron, T Pirali, RA Billington… - Medicinal research …, 2008 - Wiley Online Library
In recent years, there has been an ever‐increasing need for rapid reactions that meet the
three main criteria of an ideal synthesis: efficiency, versatility, and selectivity. Such reactions …

Chemoselective ligation and modification strategies for peptides and proteins

CPR Hackenberger… - Angewandte Chemie …, 2008 - Wiley Online Library
The investigation of biological processes by chemical methods, commonly referred to as
chemical biology, often requires chemical access to biologically relevant macromolecules …

1, 2, 3‐Triazole in heterocyclic compounds, endowed with biological activity, through 1, 3‐dipolar cycloadditions

A Lauria, R Delisi, F Mingoia, A Terenzi… - European Journal of …, 2014 - Wiley Online Library
Dipolar cycloaddition reactions can be considered a powerful synthetic tool in the building of
heterocyclic rings, with applications in different fields. In this review we focus on the …

'Click'chemistry in polymer and material science: an update

WH Binder, R Sachsenhofer - Macromolecular Rapid …, 2008 - Wiley Online Library
The metal catalyzed azide/alkyne 'click'reaction (a variation of the Huisgen 1, 3‐dipolar
cycloaddition reaction between terminal acetylenes and azides) has vastly increased in …

The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins

MG Paulick, CR Bertozzi - Biochemistry, 2008 - ACS Publications
Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol
(GPI) anchor is a posttranslational modification that anchors the modified protein in the outer …

Peptide/protein–polymer conjugates: synthetic strategies and design concepts

MA Gauthier, HA Klok - Chemical Communications, 2008 - pubs.rsc.org
This feature article provides a compilation of tools available for preparing well-defined
peptide/protein–polymer conjugates, which are defined as hybrid constructs combining (i) a …

Self-assembled peptide nanomaterials for biomedical applications: promises and pitfalls

L Sun, C Zheng, TJ Webster - International journal of …, 2017 - Taylor & Francis
Over the last several decades, a great number of advances have been made in the area of
self-assembled supramolecules for regenerative medicine. Such advances have involved …