The landmark discoveries of leptin and adiponectin firmly established adipose tissue as a
sophisticated and highly active endocrine organ, opening a new era of investigating adipose …

Adiponectin is the richest adipokine in human plasma, and it is mainly secreted from white
adipose tissue. Adiponectin circulates in blood as high-molecular, middle-molecular, and …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

A wealth of clinical and epidemiological evidence has linked obesity to a broad spectrum of
cardiovascular diseases (CVD) including coronary heart disease, heart failure …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Adenosine monophosphate-activated protein kinase (AMPK) is in charge of numerous
catabolic and anabolic signaling pathways to sustain appropriate intracellular adenosine …

During pregnancy, several tightly coordinated and regulated processes take place to enable
proper fetal development and gestational success. The formation and development of the …