Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies

S Chen, T Dai Nguyen, KZ Lee, D Liu - Biotechnology Advances, 2024 - Elsevier
Adoptive immunotherapy shows great promise as a treatment for cancer and other diseases.
Recent evidence suggests that the therapeutic efficacy of these cell-based therapies can be …

Melanoma-associated fibroblasts in tumor-promotion flammation and antitumor immunity: novel mechanisms and potential immunotherapeutic strategies

Q Zhou, X Jin, Y Zhao, Y Wang, M Tao… - Human Molecular …, 2024 - academic.oup.com
Melanoma, renowned for its aggressive behavior and resistance to conventional treatments,
stands as a formidable challenge in the oncology landscape. The dynamic and complex …

Preparation of μ-HMX/C-Based Composite Energy Composite Microspheres by Microdroplet Technology

Z Zhang, Z Lin, Y Guo, Y Liu, Y Chen, Z Xue, C An… - Langmuir, 2024 - ACS Publications
Taking μ-HMX particles as the main research subject, a set of microdroplet sphericalization
coating technology platforms was designed and constructed to realize the preparation of …

Flexible and simultaneous multi-scale bioparticle manipulation to actuate cell and drug delivery utilizing AC electrokinetic-powered microswimmer

H Sun, Z Li, Y Wu, T Chen, H Yang, L Sun - Sensors and Actuators B …, 2024 - Elsevier
Bioparticle trapping and transporting are essential processes for developing an integrated
cell and drug delivery system. Herein, we present a unique platform that effectively …

[HTML][HTML] Enrichment of T-lymphocytes from leukemic blood using inertial microfluidics toward improved chimeric antigen receptor-T cell manufacturing

MT Elsemary, MF Maritz, LE Smith, ME Warkiani… - Cytotherapy, 2024 - Elsevier
Chimeric antigen receptor cell therapy is a successful immunotherapy for the treatment of
blood cancers. However, hurdles in their manufacturing remain including efficient isolation …

Infrared Light Activated Highly Efficient Cell Therapy Using Flower‐Shaped Microstructure Device

AS Shinde, P Shinde, M Nagai, S Kar… - Advanced …, 2024 - Wiley Online Library
In this pioneering study, an infrared light‐activated highly efficient and uniform, small to large
biomolecular delivery into various cell types is developed using a flower‐shaped …

Miniaturized Engineering of Human Cells using Droplet Microfluidics

S Little - 2024 - spectrum.library.concordia.ca
Inserting foreign biomolecules into human cells is at the heart of cell engineering protocols.
By taking nucleic acids or fully formed proteins and shuttling them across the cell membrane …

Experimental models of CAR-redirected cellular therapy with CIK lymphocytes against ovarian cancer peritoneal carcinomatosis

F Galvagno - 2024 - iris.unito.it
Background Peritoneal carcinomatosis (PC) from ovarian cancer (OC) has poor prognosis
and is in need for optimized therapies. Such a clinical condition displays a composite …

[引用][C] Synergistic Effect of Osmotic and Mechanical Stimuli for Enhanced Cell Transfection

J TaeMin, HAN Yonghan, K Sungjun… - 한국생물공학회학술 …, 2024 - dbpia.co.kr
Immune cell therapy, utilizing genomic alterations to enhance antitumor immunity, has
significantly advanced cancer treatment. However, a major challenge persists in efficiently …