TMEM proteins in cancer: a review

K Schmit, C Michiels - Frontiers in pharmacology, 2018 - frontiersin.org
A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

New insights into oral squamous cell carcinoma: From clinical aspects to molecular tumorigenesis

SH Chen, SY Hsiao, KY Chang, JY Chang - International journal of …, 2021 - mdpi.com
Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide,
especially so in Taiwan. Early-or even preclinical-stage detection is critical for reducing …

A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase

H Yamamoto, Y Tobisawa, T Inubushi, F Irie… - Journal of Biological …, 2017 - ASBMB
Hyaluronan (HA) is an extremely large polysaccharide (glycosaminoglycan) involved in
many cellular functions. HA catabolism is thought to involve the initial cleavage of …

TMEM11 regulates cardiomyocyte proliferation and cardiac repair via METTL1-mediated m7G methylation of ATF5 mRNA

XZ Chen, XM Li, SJ Xu, S Hu, T Wang, RF Li… - Cell Death & …, 2023 - nature.com
The mitochondrial transmembrane (TMEM) protein family has several essential
physiological functions. However, its roles in cardiomyocyte proliferation and cardiac …

TMEM2: A missing link in hyaluronan catabolism identified?

Y Yamaguchi, H Yamamoto, Y Tobisawa, F Irie - Matrix Biology, 2019 - Elsevier
Hyaluronan (HA) is a glycosaminoglycan (GAG) composed of repeating disaccharide units
of glucuronic acid and N-acetylglucosamine. HA is an extremely long, unbranched polymer …

The cell surface hyaluronidase TMEM2 is essential for systemic hyaluronan catabolism and turnover

Y Tobisawa, N Fujita, H Yamamoto, C Ohyama… - Journal of Biological …, 2021 - ASBMB
As a major component of the extracellular matrix, hyaluronan (HA) plays an important role in
defining the biochemical and biophysical properties of tissues. In light of the extremely rapid …

DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis

NY Souren, LA Gerdes, P Lutsik, G Gasparoni… - Nature …, 2019 - nature.com
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous
system with a modest concordance rate in monozygotic twins, which strongly argues for …

TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway

S Zhang, H Dai, W Li, R Wang, H Wu, M Shen… - Cell death & …, 2021 - nature.com
Transmembrane protein (TMEM) is a family of protein that spans cytoplasmic membranes
and allows cell–cell and cell–environment communication. Dysregulation of TMEMs has …

A claudin-based molecular signature identifies high-risk, chemoresistant colorectal cancer patients

S Gowrikumar, M Primeaux, K Pravoverov, C Wu… - Cells, 2021 - mdpi.com
Identifying molecular characteristics that are associated with aggressive cancer phenotypes
through gene expression profiling can help predict treatment responses and clinical …

Review of prognostic expression markers for clear cell renal cell carcinoma

F Petitprez, M Ayadi, AL De Reyniès… - Frontiers in …, 2021 - frontiersin.org
Context: The number of prognostic markers for clear cell renal cell carcinoma (ccRCC) has
been increasing regularly over the last 15 years, without being integrated and compared …