Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the
adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of …

Understanding the progression of early human embryonic development prior to implantation
is of fundamental biological importance. Greater insights into early developmental events …

Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Pluripotent stem cells provide a powerful system to dissect the underlying molecular
dynamics that regulate cell fate changes during mammalian development. Here we report …

Summary The LRRK2 mutation G2019S is the most common genetic cause of Parkinson's
disease (PD). To better understand the link between mutant LRRK2 and PD pathology, we …

Considerable progress has been made in converting human pluripotent stem cells (hPSCs)
into functional neurons. However, the protracted timing of human neuron specification and …

Progress in retinal-cell therapy derived from human pluripotent stem cells currently faces
technical challenges that require the development of easy and standardized protocols. Here …

Human pluripotent stem cells (PSCs) exist in naive and primed states and provide important
models to investigate the earliest stages of human development. Naive cells can be …

The use of human pluripotent stem cells for laboratory studies and cell-based therapies is
hampered by their tumor-forming potential and limited ability to generate pure populations of …

Neural crest (NC) cells arise early in vertebrate development, migrate extensively and
contribute to a diverse array of ectodermal and mesenchymal derivatives. Previous models …