Cryptosporidium: Host-Parasite Interactions and Pathogenesis

DJ Pinto, S Vinayak - Current Clinical Microbiology Reports, 2021 - Springer
Abstract Purpose of Review Cryptosporidium spp.(C. hominis and C. parvum) are a major
cause of diarrhea-associated morbidity and mortality in young children globally. While C …

An update on Cryptosporidium biology and therapeutic avenues

AK Dhal, C Panda, SIL Yun, RK Mahapatra - Journal of Parasitic Diseases, 2022 - Springer
Cryptosporidium species has been identified as an important pediatric diarrheal pathogen in
resource-limited countries, particularly in very young children (0–24 months). However, the …

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus

V Greigert, I Saraav, J Son, Y Zhu, D Dayao, A Antia… - Gut …, 2024 - Taylor & Francis
Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor
settings. The majority of infections are caused by the human-specific pathogen C. hominis …

Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis

MA Carey, GL Medlock, M Alam, M Kabir… - Clinical Infectious …, 2021 - academic.oup.com
Background The protozoan parasites in the Cryptosporidium genus cause both acute
diarrheal disease and subclinical (ie, nondiarrheal) disease. It is unclear if the microbiota …

Exploratory Algorithm of a Multi-epitope-based Subunit Vaccine Candidate Against Cryptosporidium hominis: Reverse Vaccinology-Based Immunoinformatic …

M Hasan, M Mia - International Journal of Peptide Research and …, 2022 - Springer
Cryptosporidiosis is the leading protozoan-induced cause of diarrheal illness in children,
and it has been linked to childhood mortality, malnutrition, cognitive development, with …

Development of two mouse models for vaccine evaluation against Cryptosporidiosis

DA Dayao, J Jaskiewcz, S Lee, BC Oliveira… - Infection and …, 2022 - Am Soc Microbiol
Cryptosporidiosis was shown a decade ago to be a major contributor to morbidity and
mortality of diarrheal disease in children in low-income countries. A serious obstacle to …

Scalable cryopreservation of infectious Cryptosporidium hominis oocysts by vitrification

JJ Jaskiewicz, DAE Dayao, D Girouard… - PLoS …, 2023 - journals.plos.org
Cryptosporidium hominis is a serious cause of childhood diarrhea in developing countries.
The development of therapeutics is impeded by major technical roadblocks including lack of …

Intestinal parasitic infections in children from marginalised Roma communities: prevalence and risk factors

G Štrkolcová, D Fiľakovská Bobáková… - BMC Infectious …, 2024 - Springer
Background Intestinal parasitic infections remain a significant global health issue,
particularly affecting poor and marginalised populations. These infections significantly …

A highly antigenic fragment within the zoonotic Cryptosporidium parvum Gp900 glycoprotein (Domain 3) is absent in human restricted Cryptosporidium species

DAE Dayao, JJ Jaskiewicz, AS Sheoran, G Widmer… - Plos one, 2023 - journals.plos.org
We identified a fragment (Domain 3—D3) of the immunodominant sporozoite surface
glycoprotein of the zoonotic parasite Cryptosporidium gp900, which is absent C. hominis …

[HTML][HTML] Myristica fragrans Houtt. methanol extract as a promising treatment for Cryptosporidium parvum infection in experimentally immunosuppressed and …

EE El Shanawany, F Abouelmagd, NM Taha… - Veterinary …, 2024 - pmc.ncbi.nlm.nih.gov
Background and Aim: Cryptosporidiosis is a major waterborne disease affecting ruminants
and humans worldwide. It causes diarrhea and neonatal mortality in buffalo calves, and …