The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Growth and remodeling in the heart is driven by a combination of mechanical and hormonal
signals that produce different patterns of growth in response to exercise, pregnancy, and …

Introduction Cardiac hypertrophy is associated with adverse outcomes across
cardiovascular disease states. Despite strides over the last three decades in identifying …

Cardiomyocytes can adapt their size, shape, and orientation in response to altered
biomechanical or biochemical stimuli. The process by which the heart undergoes structural …

Cardiac hypertrophy, defined as an increase in mass of the heart, is a complex process
driven by simultaneous changes in hemodynamics, mechanical stimuli, and hormonal …

The fibroblast is a key mediator of wound healing in the heart and other organs, yet how it
integrates multiple time-dependent paracrine signals to control extracellular matrix synthesis …

Despite clinical observations of cardiotoxicity among cancer patients treated with tyrosine
kinase inhibitors (TKIs), the molecular mechanisms by which these drugs affect the heart …

Cardiac fibrosis is a significant component of pathological heart remodeling, yet it is not
directly targeted by existing drugs. Systems pharmacology approaches have the potential to …

Tissue expansion is a technique used clinically to grow skin in situ to correct large defects.
Despite its enormous potential, lack of fundamental knowledge of skin adaptation to …