Traditional Chinese medicine plays a significant role in the treatment of various diseases
and has attracted increasing attention for clinical applications. Vascular diseases affecting …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to
pulmonary pathologies, including lung edema and lung injury. However, in pulmonary …

Background: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced
hypertension. The recognition that Ca2+ signaling in endothelial cells promotes vasodilation …

Emerging studies have reported the mechanosensitive Piezo1 (piezo type
mechanosensitive ion channel component 1) plays essential roles in regulating the vascular …

In this study, we review mechanoregulatory roles for perlecan in load-bearing connective
tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly of elastic …

This study reviewed some new aspects of the modular proteoglycan perlecan, a colossal
proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …

Transient receptor potential vanilloid 4 (TRPV4) ion channels on the endothelial cell
membrane are widely regarded as a crucial Ca 2+ influx pathway that promotes …