Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …

The ongoing SARS-CoV-2 outbreak marks the first time that large amounts of genome
sequence data have been generated and made publicly available in near real time. Early …

Gene sequences sampled at different points in time can be used to infer molecular
phylogenies on a natural timescale of months or years, provided that the sequences in …

Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe
COVID-19. However, the immune signatures associated with immunopathology are poorly …

What are the models used in phylogenetic analysis and what exactly is involved in Bayesian
evolutionary analysis using Markov chain Monte Carlo (MCMC) methods? How can you …

Generation time varies widely across organisms and is an important factor in the life cycle,
life history and evolution of organisms. Although the doubling time (DT) has been estimated …

Time-calibrated species phylogenies are critical for addressing a wide range of questions in
evolutionary biology, such as those that elucidate historical biogeography or uncover …

Phylogenies provide a useful way to understand the evolutionary history of genetic samples,
and data sets with more than a thousand taxa are becoming increasingly common, notably …

Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize
molecular tests, treatments, vaccines, and guide public health responses. To investigate the …