Radiation-induced lung injury (RILI)

L Giuranno, J Ient, D De Ruysscher, MA Vooijs - Frontiers in oncology, 2019 - frontiersin.org
Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Radiation pneumonitis: old problem, new tricks

V Jain, AT Berman - Cancers, 2018 - mdpi.com
Radiation therapy is a major treatment modality for management of non-small cell lung
cancer. Radiation pneumonitis is a dose limiting toxicity of radiotherapy, affecting its …

European Organization for Research and Treatment of Cancer (EORTC) recommendations for planning and delivery of high-dose, high precision radiotherapy for lung …

D De Ruysscher, C Faivre-Finn, D Moeller… - Radiotherapy and …, 2017 - Elsevier
Purpose To update literature-based recommendations for techniques used in high-precision
thoracic radiotherapy for lung cancer, in both routine practice and clinical trials. Methods A …

Organs at risk radiation dose constraints

G Noël, D Antoni - Cancer/radiothérapie, 2022 - Elsevier
Dose constraints are essential for performing dosimetry, especially for intensity modulation
and for radiotherapy under stereotaxic conditions. We present the update of the …

Revisiting the dose constraints for head and neck OARs in the current era of IMRT

NP Brodin, WA Tomé - Oral oncology, 2018 - Elsevier
Head and neck cancer poses a particular challenge in radiation therapy, whilst being an
effective treatment modality it requires very high doses of radiation to provide effective …

Promising biomarkers of radiation-induced lung injury: a review

X Liu, C Shao, J Fu - Biomedicines, 2021 - mdpi.com
Radiation-induced lung injury (RILI) is one of the main dose-limiting side effects in patients
with thoracic cancer during radiotherapy. No reliable predictors or accurate risk models are …

Deep learning–based 4D‐synthetic CTs from sparse‐view CBCTs for dose calculations in adaptive proton therapy

A Thummerer, C Seller Oria, P Zaffino, S Visser… - Medical …, 2022 - Wiley Online Library
Background Time‐resolved 4D cone beam–computed tomography (4D‐CBCT) allows a
daily assessment of patient anatomy and respiratory motion. However, 4D‐CBCTs suffer …

Radiation pneumonitis in lung cancer patients treated with chemoradiation plus durvalumab

N Shaverdian, M Thor, AF Shepherd, MD Offin… - Cancer …, 2020 - Wiley Online Library
Introduction Durvalumab after concurrent chemoradiation (cCRT) is now standard of care for
unresected stage III non–small cell lung cancer (NSCLC). However, there is limited data on …

Phase I and pharmacologic study of olaparib in combination with high-dose radiotherapy with and without concurrent cisplatin for non–small cell lung cancer

R de Haan, MM van den Heuvel, J van Diessen… - Clinical Cancer …, 2021 - AACR
Purpose: To identify an MTD of olaparib, a PARP inhibitor, in combination with loco-regional
radiotherapy with/without cisplatin for the treatment of non–small cell lung cancer (NSCLC) …

Clinical suitability of deep learning based synthetic CTs for adaptive proton therapy of lung cancer

A Thummerer, C Seller Oria, P Zaffino… - Medical …, 2021 - Wiley Online Library
Purpose Adaptive proton therapy (APT) of lung cancer patients requires frequent volumetric
imaging of diagnostic quality. Cone‐beam CT (CBCT) can provide these daily images, but x …