Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Skeletal muscle stem and progenitor cells including those derived from human pluripotent
stem cells (hPSCs) offer an avenue towards personalized therapies and readily fuse to form …

Skeletal muscle, which comprises a significant portion of the body, is responsible for vital
functions such as movement, metabolism, and overall health. However, severe injuries often …

In vitro-generated pluripotent stem cell (PSC)-derived Pax3-induced (iPax3) myogenic
progenitors display an embryonic transcriptional signature, but upon engraftment, the profile …

Muscular dystrophy encompasses a large number of heterogeneous genetic disorders
characterized by progressive and devastating muscle wasting. Cell-based replacement …

Satellite cells, the stem cells of skeletal muscle tissue, hold a remarkable regeneration
capacity and therapeutic potential in regenerative medicine. However, low satellite cell yield …

In vitro culture systems that structurally model human myogenesis and promote PAX7+
myogenic progenitor maturation have not been established. Here we report that human …

Pluripotent stem cell (PSC)-based cell therapy is an attractive option for the treatment of
multiple human disorders, including muscular dystrophies. While in vitro differentiating PSCs …

Ongoing, first-in-human clinical trials illustrate the feasibility and translational potential of
human pluripotent stem cell (hPSC)-based cell therapies in Parkinson's disease (PD) …

The generation of myogenic progenitors from iPSCs (iMPs) with therapeutic potential for in
vivo tissue regeneration has long been a goal in the skeletal muscle community. Today …