IQGAP proteins have been identified in a wide spectrum of organisms, ranging from yeast to
humans. The most extensively studied family member is the ubiquitously expressed scaffold …

Since its discovery in 1994, recognized cellular functions for the scaffold protein IQGAP1
have expanded immensely. Over 100 unique IQGAP1-interacting proteins have been …

Solid tumors elicit a detectable immune response including the infiltration of tumor-
associated macrophages (TAMs). Unfortunately, this immune response is co-opted into …

Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality.
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …

The intracellular spatiotemporal organization of signaling events is critical for normal cellular
function. In response to environmental stimuli, cells utilize highly organized signaling …

Fluorescence cross-correlation spectroscopy (FCCS) is used to determine interactions and
dissociation constants (K ds) of biomolecules. The determination of a K d depends on the …

Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV
astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain …

IQGAP1 is a multifunctional protein involved in actin cytoskeleton assembly and E‐cadherin‐
mediated cell adhesion. We reported previously IQGAP1 overexpression in human …

General or brain-region-specific decreases in spine number or morphology accompany
major neuropsychiatric disorders. It is unclear, however, whether changes in spine density …

The quantification of biological interactions is very important in life sciences. Here we report
for the first time, to our knowledge, the determination of a biomolecular dissociation constant …