Modifiable risk and protective factors for boosting brain and cognitive development and
preventing neurodegeneration and cognitive decline are embraced in neuroimaging …

As the global population faces a progressive shift towards a higher median age,
understanding the mechanisms underlying healthy brain ageing has become of paramount …

Older adults with lower education are at greater risk for dementia. It is unclear which brain
changes lead to these outcomes. Longitudinal imaging-based measures of brain structure …

Higher educational attainment is observationally associated with lower risk of Alzheimer's
disease. However, the biological mechanisms underpinning this association remain unclear …

Biologically based senescence processes and cumulative opportunities for experience
collectively give rise to profound changes in cognition in later adulthood, the trajectories of …

Many believe that engaging in novel and mentally challenging activities promotes brain
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …

Medial temporal lobe (MTL) atrophy is a key feature of Alzheimer's disease (AD), however, it
also occurs in typical aging. To enhance the clinical utility of this biomarker, we need to …

It is well documented that some brain regions, such as association cortices, caudate, and
hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized …

From a biological perspective, humans differ in the speed they age, and this may manifest in
both mental and physical health disparities. The discrepancy between an individual's …

The brain‐age‐gap estimate (brainAGE) quantifies the difference between chronological
age and age predicted by applying machine‐learning models to neuroimaging data and is …