Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

Myocardial infarction (MI) is one of the most common cardiac emergencies with high
morbidity and is a leading cause of death worldwide. Since MI could develop into a life …

A continuous supply of oxygen is essential for the survival of multicellular organisms. The
understanding of how this supply is regulated in the microvasculature has evolved from …

A decline in the function of the microvasculature occurs with ageing. An impairment of
endothelial properties represents a main aspect of age-related microvascular alterations …

Rationale: Inflammation in post–myocardial infarction (MI) is necessary for myocyte repair
and wound healing. Unfortunately, it is also a key component of subsequent heart failure …

Retinal ischemia is a major cause of visual impairment and blindness and is involved in
various disorders including diabetic retinopathy, glaucoma, optic neuropathies and …

Aging results in functional and structural changes in the cardiovascular system, translating
into a progressive increase of mechanical vessel stiffness, due to a combination of changes …

Endothelial dysfunction represents an early change in the vascular wall in areas prone to
atherosclerotic plaque formation and is present in association with several risk factors for …