Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules

RM Maizels, HH Smits, HJ McSorley - Immunity, 2018 - cell.com
Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Immune regulation by helminth parasites: cellular and molecular mechanisms

RM Maizels, M Yazdanbakhsh - Nature Reviews Immunology, 2003 - nature.com
Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

Signalling C‐type lectin receptors, microbial recognition and immunity

JC Hoving, GJ Wilson, GD Brown - Cellular microbiology, 2014 - Wiley Online Library
Signalling C‐type lectin receptors (CLR s) are crucial in shaping the immune response to
fungal pathogens, but comparably little is known about the role of these receptors in …

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins

O Blixt, S Head, T Mondala… - Proceedings of the …, 2004 - National Acad Sciences
Here we describe a glycan microarray constructed by using standard robotic microarray
printing technology to couple amine functionalized glycans to an amino-reactive glass slide …

DC-SIGN: escape mechanism for pathogens

Y van Kooyk, TBH Geijtenbeek - Nature Reviews Immunology, 2003 - nature.com
Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are
recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on …

Helminth parasites–masters of regulation

RM Maizels, A Balic, N Gomez‐Escobar… - Immunological …, 2004 - Wiley Online Library
Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori

SI Gringhuis, J Den Dunnen, M Litjens… - Nature …, 2009 - nature.com
Cooperation between different innate signaling pathways induced by pattern-recognition
receptors (PRRs) on dendritic cells (DCs) is crucial for tailoring adaptive immunity to …

Fucosylation in prokaryotes and eukaryotes

B Ma, JL Simala-Grant, DE Taylor - Glycobiology, 2006 - academic.oup.com
Fucosylated carbohydrate structures are involved in a variety of biological and pathological
processes in eukaryotic organisms including tissue development, angiogenesis, fertilization …

Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN

KPJM van Gisbergen, M Sanchez-Hernandez… - The Journal of …, 2005 - rupress.org
Neutrophils are key players of the innate immune system that provide a first line of defense
against invading pathogens. However, it is unknown whether neutrophils can interact with …