The advent of the genomic era has opened up enormous possibilities for the discovery of
new natural products. Also known as specialized metabolites, these compounds produced …

Many enzymes in nature utilize a free arginine (L-Arg) amino acid to initiate the biosynthesis
of natural products. Examples include nitric oxide synthases, which generate NO from L-Arg …

Mining large-scale functional regions of the genome helps to understand the essence of
cellular life. The rapid accumulation of genomic information provides a wealth of material for …

Since the discovery of penicillin, natural products and their derivatives have been a valuable
resource for drug discovery. With recent development of genome mining approaches in the …

Nocardia are opportunistic human pathogens that can cause a range of debilitating and
difficult to treat infections of the lungs, brain, skin, and soft tissues. Despite their close …

Transformation-associated recombination (TAR) cloning represents a unique tool to
selectively and efficiently recover a given chromosomal segment up to several hundred kb in …

Nosiheptide (NOS) is a thiopeptide antibiotic produced by the bacterium Streptomyces
actuosus. The hydroxyl group of 3‐hydroxypyridine in NOS has been identified as a …

We report an improved de novo draft genome sequence of the human-pathogenic strain
Nocardia terpenica IFM 0706T. The resequencing unveiled that the genome size is larger …

The cloning and heterologous expression of natural product biosynthetic gene clusters has
helped to identify many new bioactive molecules and conclusively connect genes to …

ASBMB 2022 poster_Jones_for printing Page 1 Biosynthesis of VPCA requires a three-enzyme
mini-pathway. The heme-dependent L-tyrosine hydroxylase (ie LmbB2) is a peroxidase that …