Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal
disorder. Two US Food and Drug Administration–approved antifibrotic drugs, nintedanib and …

Abstract Objective FTY720, a sphingosine‐1‐phosphate (S1P) receptor agonist that crosses
the blood–brain barrier, is a potential immuno‐therapy for multiple sclerosis. Our objective …

Drug-induced suppression of female schistosome sexual maturation is an auspicious
strategy to combat schistosomiasis since the eggs are the causative agent. The …

In addition to transporting ions, the multisubunit Na+, K+-ATPase also functions by relaying
cardiotonic steroid (CTS)-binding-induced signals into cells. In this study, we analyzed the …

Background Bone loss, in malignant or non-malignant diseases, is caused by increased
osteoclast resorption and/or reduced osteoblast bone formation, and is commonly …

Fluorescent biosensors for living cells currently require laborious optimization and a unique
design for each target. They are limited by the availability of naturally occurring ligands with …

The obligate intracellular bacterial pathogen Chlamydia trachomatis is a major cause of
blindness and sexually transmitted diseases. Like the enteric pathogens Salmonella and …

Although c-Abl and Arg non–receptor tyrosine kinases are well known for driving leukemia
development, their role in solid tumors has not been appreciated until recently …

Integrins are important mediators of cell adhesion and migration, which in turn are essential
for diverse biological functions, including wound healing and cancer metastasis. The …

c-Yes, a member of the Src tyrosine kinase family, is found highly activated in colon
carcinoma but its importance relative to c-Src has remained unclear. Here we show that, in …