Pathway analysis using XGBoost classification in Biomedical Data

GN Dimitrakopoulos, AG Vrahatis… - Proceedings of the 10th …, 2018 - dl.acm.org
Given the fact that our biological existence is rooted in a complex system within our cells
with thousands of interactions among genes and metabolites, research community in …

Cognitive reorganization due to mental workload: A functional connectivity analysis based on working memory paradigms

GN Dimitrakopoulos, I Kakkos, A Anastasiou… - Applied Sciences, 2023 - mdpi.com
Mental workload has a major effect on the individual's performance in most real-world tasks,
which can lead to significant errors in critical operations. On this premise, the analysis and …

Identification of orphan genes in unbalanced datasets based on ensemble learning

Q Gao, X Jin, E Xia, X Wu, L Gu, H Yan, Y Xia… - Frontiers in genetics, 2020 - frontiersin.org
Orphan genes are associated with regulatory patterns, but experimental methods for
identifying orphan genes are both time-consuming and expensive. Designing an accurate …

XGRN: reconstruction of biological networks based on boosted trees regression

GN Dimitrakopoulos - Computation, 2021 - mdpi.com
In Systems Biology, the complex relationships between different entities in the cells are
modeled and analyzed using networks. Towards this aim, a rich variety of gene regulatory …

A single-cell Systems Biology approach for disease-specific subpathway extraction

AG Vrahatis, GN Dimitrakopoulos… - … IEEE conference on …, 2019 - ieeexplore.ieee.org
Single-cell sequencing technologies offer a platform to explore deeper the complex
diseases and biological processes. On parallel, Systems Biology approaches can tackle part …

Detecting perturbed subpathways towards mouse lung regeneration following H1N1 influenza infection

AG Vrahatis, K Dimitrakopoulou, A Kanavos, S Sioutas… - Computation, 2017 - mdpi.com
It has already been established by the systems-level approaches that the future of predictive
disease biomarkers will not be sketched by plain lists of genes or proteins or other biological …

Detecting Common Pathways and Key Molecules of Neurodegenerative Diseases from the Topology of Molecular Networks

AG Vrahatis, IS Kotsireas, P Vlamos - GeNeDis 2018: Computational …, 2020 - Springer
Abstract Motivation Neurodegenerative diseases (NDs), including amyotrophic lateral
sclerosis, Parkinson's disease, Alzheimer's disease, and Huntington's disease, occur as a …

A systems biology approach for the identification of active molecular pathways during the progression of Alzheimer's disease

AG Vrahatis, IS Kotsireas, P Vlamos - GeNeDis 2018: Computational …, 2020 - Springer
Motivation In the last years, systems-level network-based approaches have gained ground
in the research field of systems biology. These approaches are based on the analysis of …

[PDF][PDF] XGRN: Reconstruction of Biological Networks Based on Boosted Trees Regression. Computation 2021, 9, 48

GN Dimitrakopoulos - 2021 - pdfs.semanticscholar.org
In Systems Biology, the complex relationships between different entities in the cells are
modeled and analyzed using networks. Towards this aim, a rich variety of gene regulatory …

[PDF][PDF] к. б. н., доцент Иванисенко ВА

ОВ Сайк - icgbio.ru
В настоящее время согласно Международной Классификации Болезней (МКБ)
выделяют около 20 тысяч различных заболеваний (Gersenovic, 1995), которые …