Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …

Programmable nucleases—including zinc-finger nucleases (ZFNs), transcription activator-
like effector nucleases (TALENs) and RNA-guided engineered nucleases (RGENs) derived …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

New technologies have recently emerged that enable targeted editing of genomes in
diverse systems. This includes precise manipulation of gene sequences in their natural …

Conspectus The understanding of gene regulation and the structure and function of the
human genome increased dramatically at the end of the 20th century. Yet the technologies …

Genome engineering—the ability to precisely alter the DNA information in living cells—is
beginning to transform human genetics and genomics. Advances in tools and methods have …

The delivery of CRISPR/Cas systems holds immense potential for revolutionizing cancer
treatment, with recent advancements focusing on extracellular vesicles (EVs) and viral …

Objective: The aim of this paper is to investigate the effect of dendrosomal curcumin (DNC)
on the expression of p53 in both p53 mutant cell lines SKBR3/SW480 and p53 wild-type …

Zinc-finger nucleases: how to play two good hands | Nature Methods Skip to main content
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The ability to enrich cells with targeted mutations greatly facilitates the process of using
engineered nucleases, including zinc-finger nucleases and transcription activator-like …