The amyloid cascade hypothesis has always been a research focus in the therapeutic field
of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to …

Alzheimer's disease (AD) is the most common cause of dementia in the general population
and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD …

The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

The SARS-CoV-2 virus gains entry to cells by binding to angiotensin-converting enzyme 2
(ACE2). Since circumventricular organs and parts of the hypothalamus lack a blood–brain …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
cognitive decline, amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) …

Ischemic stroke is an inflammation-related disease, during which process activation of
NLRP3 inflammasome and subsequent pyroptosis play crucial roles. Platelet-activating …

Nanoparticles (NPs) that target multiple transport mechanisms facilitate targeted delivery of
active therapeutic agents to the central nervous system (CNS) and improve therapeutic …

Chronic inflammation is defined by an activated microglial state linked to all neurological
disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. In addition to
amyloid beta (Aβ) and tau, neuroinflammation is a crucial element in the etiology of this …

Neuroinflammation is the major implication of neurodegeneration. This is a complex process
which initiates from the cellular injury triggering the innate immune system which gives rise …