The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

It is becoming increasingly apparent that beta cell dysfunction resulting in abnormal insulin
secretion is the essential element in the progression of patients from a state of impaired …

Insulin secretion from pancreatic islet beta cells is acutely regulated by a complex interplay
of metabolic and electrogenic events. The electrogenic mechanism regulating insulin …

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …

Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment protein
receptor (SNARE) complex proteins in the B-cells. We assessed insulin release as well as …

Membrane vesicle traffic to and from the plasma membrane is essential for cellular
homeostasis in all eukaryotes [1–3]. In plants, constitutive traffic to and from the plasma …

Junctions between cortical endoplasmic reticulum (cER) and the plasma membrane are a
subtle but ubiquitous feature in mammalian cells; however, very little is known about the …

Recent findings indicate that proteins in the SNARE superfamily are essential for cell
signaling, in addition to facilitating vesicle traffic in plant cell homeostasis, growth, and …

In pancreatic β-cells, the predominant voltage-gated Ca 2+ channel (Ca V 1.2) and K+
channel (KV 2.1) are directly coupled to SNARE (soluble N-ethylmaleimide-sensitive factor …

Cardiac myocytes are characterized by distinct structural and functional entities involved in
the generation and transmission of the action potential and the excitation-contraction …