The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form
of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site …

FtsZ polymerizes into protofilaments to form the Z-ring that acts as a scaffold for accessory
proteins during cell division. Structures of FtsZ have been previously solved, but detailed …

FtsZ is a key molecule in bacterial cell division. In the presence of GTP, it polymerizes into
tubulin-like protofilaments by head-to-tail association. Protofilaments of FtsZ seem to adopt a …

More than two decades have elapsed since the publication of the first genome sequence of
Mycobacterium tuberculosis (Mtb) which, shortly thereafter, enabled methods to determine …

The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a
structure at the division site termed the “Z ring”. During cytokinesis, the Z ring exerts a …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Assembly of the cytoskeletal protein FtsZ into a ring‐like structure is required for bacterial
cell division. Structurally, FtsZ consists of four domains: the globular N‐terminal core, a …

With the emergence of multidrug-resistant bacterial strains, there is a dire need for new drug
targets for antibacterial drug discovery and development. Filamentous temperature sensitive …

Tuberculosis (TB) is the fastest spreading infectious disease and one of the top ten diseases
that kill millions of people annually. The rapid spread of a multidrug‐resistant strain of …