Pyoderma gangrenosum

E Maverakis, AV Marzano, ST Le, JP Callen… - Nature Reviews …, 2020 - nature.com
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that presents with rapidly
developing, painful skin ulcers hallmarked by undermined borders and peripheral erythema …

Targeting immune cell circuits and trafficking in inflammatory bowel disease

MF Neurath - Nature immunology, 2019 - nature.com
Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …

Ulcerative colitis (primer)

T Kobayashi, B Siegmund, C Le Berre… - Nature Reviews …, 2020 - search.proquest.com
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown aetiology
affecting the colon and rectum. Multiple factors, such as genetic background, environmental …

The human microbiome in disease and pathology

J Manos - Apmis, 2022 - Wiley Online Library
This narrative review seeks to examine the relationships between bacterial microbiomes
and infectious disease. This is achieved by detailing how different human host microbiomes …

The IL-1 family cytokines and receptors in autoimmune diseases

P Migliorini, P Italiani, F Pratesi, I Puxeddu… - Autoimmunity …, 2020 - Elsevier
The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

Inhibiting interleukin 36 receptor signaling reduces fibrosis in mice with chronic intestinal inflammation

K Scheibe, C Kersten, A Schmied, M Vieth, T Primbs… - Gastroenterology, 2019 - Elsevier
Background & Aims Intestinal fibrosis is a long-term complication in inflammatory bowel
diseases (IBD) that frequently results in functional damage, bowel obstruction, and surgery …

Cytokines in inflammatory bowel diseases–update 2020

M Leppkes, MF Neurath - Pharmacological Research, 2020 - Elsevier
Abstract Inflammatory Bowel Diseases (IBD), namely Crohn's Disease and Ulcerative Colitis,
cause a significant disease burden in modern civilization. Ever since the introduction of anti …

Regulation and function of interleukin‐36 cytokines

EY Bassoy, JE Towne, C Gabay - Immunological reviews, 2018 - Wiley Online Library
Summary The interleukin (IL)‐36 cytokines include 3 agonists, IL‐36α, IL‐36β, and IL‐36γ
that bind to a common receptor composed of IL‐36R and IL‐1 RA cP to stimulate …

Inflammatory cytokines: from discoveries to therapies in IBD

I Marafini, S Sedda, V Dinallo… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Although the etiology of inflammatory bowel diseases (IBD) remains unknown,
accumulating evidence suggests that the intestinal tissue damage in these disorders is due …

Novel mechanisms and clinical trial endpoints in intestinal fibrosis

J Wang, S Lin, JM Brown, D van Wagoner… - Immunological …, 2021 - Wiley Online Library
The incidence of inflammatory bowel diseases (IBD) worldwide has resulted in a global
public health challenge. Intestinal fibrosis leading to stricture formation and bowel …