The complement system in age-related macular degeneration

A Armento, M Ueffing, SJ Clark - Cellular and Molecular Life Sciences, 2021 - Springer
Age-related macular degeneration (AMD) is a chronic and progressive degenerative
disease of the retina, which culminates in blindness and affects mainly the elderly …

Choriocapillaris: fundamentals and advancements

R Lejoyeux, J Benillouche, J Ong, MH Errera… - Progress in Retinal and …, 2022 - Elsevier
The choriocapillaris is the innermost structure of the choroid that directly nourishes the
retinal pigment epithelium and photoreceptors. This article provides an overview of its …

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

AP Voigt, K Mulfaul, NK Mullin… - Proceedings of the …, 2019 - National Acad Sciences
The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide
crucial support to the retina. Disease affecting either of these supportive tissues can lead to …

Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration

KS Lee, S Lin, DA Copland, AD Dick, J Liu - Journal of Neuroinflammation, 2021 - Springer
Age-related macular degeneration (AMD), a degenerative disease in the central macula
area of the neuroretina and the supporting retinal pigment epithelium, is the most common …

Bioprinted 3D outer retina barrier uncovers RPE-dependent choroidal phenotype in advanced macular degeneration

MJ Song, R Quinn, E Nguyen, C Hampton, R Sharma… - Nature …, 2023 - nature.com
Age-related macular degeneration (AMD), a leading cause of blindness, initiates in the outer-
blood-retina-barrier (oBRB) formed by the retinal pigment epithelium (RPE), Bruch's …

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Age-related macular degeneration: A two-level model hypothesis

MP Rozing, JA Durhuus, MK Nielsen, Y Subhi… - Progress in retinal and …, 2020 - Elsevier
Age-related diseases, including age-related macular degeneration (AMD), are of growing
importance in a world where population ageing has become a dominant global trend …

Age-related macular degeneration revisited: From pathology and cellular stress to potential therapies

M Hadziahmetovic, G Malek - Frontiers in cell and developmental …, 2021 - frontiersin.org
Age-related macular degeneration (AMD) is a neurodegenerative disease of the aging
retina, in which patients experience severe vision loss. Therapies available to patients are …

[WITHDRAWN] retinal vasculature in development and diseases

Y Sun, LEH Smith - Annual review of vision science, 2018 - annualreviews.org
This article was withdrawn on October 15, 2020, at the request of the journal editors, with
agreement from the authors, owing to a substantial amount of unattributed or improperly …