Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also referred to
as drug-induced hypersensitivity syndrome, is a distinct, potentially life-threatening adverse …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

Resolving conflict of interest The Joint Task Force on Practice Parameters (JTFPP) is
committed to ensuring that all guidelines are based on the best scientific evidence at the …

BACKGROUND: Increasing studies have revealed that HLA alleles are the major genetic
determinants of drug hypersensitivity; however, the underlying molecular mechanism …

A previous study conducted in Taiwan found a 100% association between HLA‐B* 1502
allele and carbamazepine‐induced Stevens‐Johnson syndrome (SJS) in Han Chinese …

BACKGROUND: Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal
necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses …

The Drug Reaction with Eosinophilia and Systemic Symptoms syndrome, also known as
Drug Induced Hypersensitivity Syndrome presents clinically as an extensive mucocutaneous …

Immune reactions to small molecular compounds such as drugs can cause a variety of
diseases mainly involving skin, but also liver, kidney, lungs and other organs. In addition to …

Although idiosyncratic adverse drug reactions are rare, they are still a major concern to
patient safety. Reactive metabolites are widely accepted as playing a pivotal role in the …

Immunologically mediated drug reactions have been traditionally classified as unpredictable
based on the fact that they cannot be predicted strictly on the pharmacological action of the …